WHSC1 (NSD2)

Background Information:

WHSC1 (Wolf-Hirschhorn syndrome candidate 1), also known as NSD2 (nuclear receptor binding SET domain protein 2), is a histone methyltransferase that adds methyl groups to histone H3 lysine 36 (H3K36). WHSC1/NSD2 is part of a family of SET domain-containing proteins that includes the closely related NSD1 and NSD3 proteins. WHSC1/NSD2 is involved in the regulation of gene expression, and has been shown to play a role in various cellular processes, including cell cycle progression, DNA damage response, and the maintenance of genomic stability.
WHSC1/NSD2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.

Target Class:

Epigenetic

Family:

Histone Methyltransferase (HMT)

Sub Family:

Writer

Protein Name:

NSD2

Protein Aliases:

multiple myeloma SET domain containing protein|nuclear receptor binding SET domain protein 2

Accession Number:

NM_001042424.3

UniProt Number:

O96028

Gene Name:

WHSC1

Gene ID:

7468

Gene Aliases:

MMSET|NSD2

Target Species:

Human