ULK3, active

Background Information:

ULK3 (Unc-51 Like Kinase 3) is a Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. It acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). It also positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. ULK3 Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. GenBank XM_044630 (DNA has been codon optimized for insect cell expression)

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

ULK3

Protein Aliases:

Unc-51-like kinase 3

Accession Number:

XM_044630.12

UniProt Number:

Q6PHR2

Gene Name:

ULK3

Gene ID:

25989

Gene Aliases:

DKFZP434C131|FLJ90566

Target Species:

Human