TTK, active

Background Information:

TTK is a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

TTK

Protein Aliases:

cancer/testis antigen 96|monopolar spindle 1 kinase

Accession Number:

NM_003318.3

UniProt Number:

P33981

Gene Name:

TTK

Gene ID:

7272

Gene Aliases:

MPS1|MPS1L1|CT96|MPH1

Target Species:

Human