TAK1-TAB1 Fusion, active

Background Information:

TAK1-TAB1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. GenBank NM_003188

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

TAK1

Protein Aliases:

TGF-beta activated kinase 1

Accession Number:

NM_003188.2; NM_145331.1; NM_145332.1; NM_145333.1

UniProt Number:

O43318

Gene Name:

MAP3K7

Gene ID:

6885

Gene Aliases:

MEKK7|TAK1

Target Species:

Human