Biological Information

Background Information:

SYK tyrosine kinase (spleen tyrosine kinase) is a key molecule in the development of the B cell lineage and the activation of B lymphocytes after Ag recognition by the B-cell receptor. Syk binds to ITAM motifs and initiates signaling pathway such as Ras, PI3 Kinase, Ca2+ flux , and PLCγ2. SYK is required for early B cell development. GenBank L28824

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

Syk

Protein Aliases:

Spleen tyrosine kinase|p72-Syk

Accession Number:

L28824.1

UniProt Number:

P43405

Gene Name:

SYK

Gene ID:

6850

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology