Biological Information

Background Information:

Rho-associated, coiled-coil containing protein kinase (ROCK), including the ROCK1 and ROCK2 isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. PKA and the two ROCKs have been reported to have opposite effects on neurite formation. More studies are needed to provide significant insights into the role of ROCK in several pathological processes. ROCK inhibitors have been shown the benefit for treatment of various cancers, inflammation, coronary artery spasms and hypertension. GenBank NM_005406

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

ROCK1

Protein Aliases:

Renal carcinoma antigen NY-REN-35|Rho-associated, coiled-coil-containing protein kinase 1|Rho-associated, coiled-coil-containing protein kinase I|ROCK-I|p160 ROCK-1|p160ROCK

Accession Number:

NM_005406.2

UniProt Number:

Q13464

Gene Name:

ROCK1

Gene ID:

6093

Gene Aliases:

p160ROCK

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology