RIG-I, active

Background Information:

RIG-I is a pattern recognition innate immune receptor that belongs to the DEA(X)D-box family of helicases. It belongs to a family of double‐stranded RNA (dsRNA) binding proteins that includes two other innate immune surveillance proteins, MDA5 and LGP2. This family of proteins, known as the RIG‐I‐like receptors or RLRs, provide broad protection against viral infections by recognizing and responding to different types of viral RNA motifs. RIG-I initiates innate antiviral immunity by sensing short dsRNA and triggering a signalling cascade resulting in the release of type I interferons to control the viral infection and prime the adaptive response. Dysregulation/mutation of RIG-I, MDA5 and DHX58 (LGP2) has been implicated in abnormal inflammatory responses to viral infections as well as autoimmune diseases.

Target Class:

Helicase

Family:

RLR

Sub Family:

RNA helicase

Protein Aliases:

RLR-1, RIGI, RIG-1, DDX58

Accession Number:

NM_014314.4

UniProt Number:

O95786

Target Species:

Human