Biological Information
Background Information:
The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschsprung disease or colonic aganglionosis). GenBank NM_000323
Target Class:
Kinase
Family:
RTK
Sub Family:
Protein Tyrosine
Protein Name:
Ret
Protein Aliases:
cadherin-related family member 16|RET receptor tyrosine kinase|rearranged during transfection
Accession Number:
NM_000323
UniProt Number:
P07949
Gene Name:
RET
Gene ID:
5979
Gene Aliases:
PTC|CDHF12|RET51|CDHR16
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage disclaimer:
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Assay Information
Assay Type:
Enzymatic
Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology