Biological Information

Background Information:

The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschsprung disease or colonic aganglionosis). GenBank NM_000323

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Ret

Protein Aliases:

cadherin-related family member 16|RET receptor tyrosine kinase|rearranged during transfection

Accession Number:

NM_000323

UniProt Number:

P07949

Gene Name:

RET

Gene ID:

5979

Gene Aliases:

PTC|CDHF12|RET51|CDHR16

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology