Ready-to-Assay SST5 Somatostatin Receptor Frozen Cells

Background Information:

The Ready-to-Assay SST5 Somatostatin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. somatostatin) based activation of SSTR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress SSTR5 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR5 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

Somatostatin

Sub Family:

Class A

Protein Name:

sst5

Protein Aliases:

SS5-R|SS5R

Accession Number:

NM_001053.1

UniProt Number:

P35346

Gene Name:

SSTR5

Gene ID:

6755

Target Species:

Human

Cell Background:

Chem-1