Ready-to-Assay P2Y4 Purinergic Receptor Frozen Cells

Background Information:

The Ready-to-Assay P2Y4 Purinergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. ATP, UTP) based activation of P2RY4 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress P2RY4 , a naturally Gq coupled GPCR. Upon activation of P2RY4 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

P2Y

Sub Family:

Class A

Protein Name:

P2Y4

Protein Aliases:

P2P|Uridine nucleotide receptor|UNR

Accession Number:

NM_002565.3

UniProt Number:

P51582

Gene Name:

P2RY4

Gene ID:

5030

Gene Aliases:

NRU|P2Y4|UNR|P2P

Target Species:

Human

Cell Background:

1321N1