Raf-1 (truncated), active

Background Information:

Raf-1 is the cellular homolog of viral Raf gene (v-Raf). The encoded protein is a MAP Kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. EMBL X03484

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

c-Raf (Raf-1)

Protein Aliases:

C-Raf proto-oncogene, serine/threonine kinase

Accession Number:

NM_002880.2

UniProt Number:

P04049

Gene Name:

RAF1

Gene ID:

5894

Gene Aliases:

Raf-1|c-Raf|CRAF

Target Species:

Human