Biological Information

Background Information:

The PrecisION™ hERG Recombinant Stable Cell Line is a stable, engineered cell line for use in studying hERG ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses hERG ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Ion Channel

Family:

Potassium

Sub Family:

Voltage-Gated

Protein Name:

hERG

Protein Aliases:

Ether-a-go-go-related gene potassium channel 1|ERG-1|Eag-related protein 1|Ether-a-go-go-related protein 1|H-ERG|hERG-1|hERG1|Voltage-gated potassium channel subunit Kv11.1

Accession Number:

U04270

UniProt Number:

Q12809

Gene Name:

KCNH2

Gene ID:

3757

Gene Aliases:

Kv11.1|HERG|erg1

Target Species:

Human

Cell Background:

CHO-K1

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Electrophysiology

Detection Method:

Electrophysiology

Additional Information

Brand:

PrecisION™