PRAK, unactive

Background Information:

Protein Serine/Threonine Kinase MAPKAPK5 (mitogen-activated protein kinase activated protein kinase 5), also known as p38-regulated/activated protein kinase (PRAK), functions downstream of p38a and p38b in mediating signaling of the p38 pathway. This kinase can be activated in response to cellular stress and proinflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. MAPKAPK5 is localized predominantly in the cytoplasm and is constantly shuttled between the cytoplasm and the nucleus. MAPKAPK5 may play a role in balancing other MAPK pathways because over-activation of MAPKAPK5 can inhibit Ras mediated cell proliferation and gene activation. MAPKAPK5 inhibition may facilitate cell differentiation, inflammation and cell proliferation. EMBL AF032437. Protein is R291E with respect to this accession. This conflict is reported in GenBank AI300977, AL556217 and BI495728.

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

PRAK

Protein Aliases:

MAPKAP kinase 5|MAPKAP-K5|MAPKAPK-5|MK-5|MK5|p38-regulated/activated protein kinase|PRAK

Accession Number:

NM_003668.2; NM_139078.1

UniProt Number:

Q8IW41

Gene Name:

MAPKAPK5

Gene ID:

8550

Gene Aliases:

PRAK

Target Species:

Human