PKG1beta, active

Background Information:

In smooth muscle cells, one of the major receptors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase 1, beta isozyme (PRKG1B). PRKG1 has been shown to catalyze the phosphorylation of a number of physiologically relevant proteins whose function it is to regulate the contractile activity of the smooth muscle cell. Two main types of PRKG are present in eukaryotic cells. Type I is widely distributed and is isolated from soluble extracts of tissues, such as cardiac and smooth muscle, as well as lymphoid cells. Type II is a particulate form of the enzyme and has a limited tissue distribution. GenBank NM_006258

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

PKG1

Protein Aliases:

cGK1|cGMP-dependent protein kinase I|cGKI

Accession Number:

NM_001098512.1; NM_006258.2

UniProt Number:

Q13976

Gene Name:

PRKG1

Gene ID:

5592

Gene Aliases:

PGK|PKG|PRKG1B|PRKGR1A|PRKGR1B

Target Species:

Human