Biological Information

Background Information:

Protein kinase Cm (PKCm) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters. GenBank NM_002742

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

PKCmu (PKD1)

Protein Aliases:

Protein kinase C mu type|Protein kinase D|nPKC-D1|nPKC-mu

Accession Number:

NM_002742.2

UniProt Number:

Q15139

Gene Name:

PRKD1

Gene ID:

5587

Gene Aliases:

PKCM|PKD|PKC-mu|PKD1|PRKCM

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology