PIP4K2alpha, active

Background Information:

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. GenBank NM_005028

Target Class:

Kinase

Family:

PIP Type I

Sub Family:

Lipid

Protein Name:

PIP4K2alpha

Accession Number:

NM_005028

UniProt Number:

P48426

Gene Name:

PIP4K2A

Gene ID:

5305

Gene Aliases:

PIP5KIIA|PIP5KIIalpha

Target Species:

Human