PIK3C3, active

Background Information:

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways. PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. GenBank BC053651

Target Class:

Kinase

Family:

PtdIns 3-Kinase

Sub Family:

Lipid

Protein Name:

VPS34

Protein Aliases:

PI3K type 3|PtdIns-3-kinase type 3|Phosphatidylinositol 3-kinase p100 subunit|Phosphoinositide-3-kinase class 3|hVps34

Accession Number:

BC053651

UniProt Number:

Q8NEB9

Gene Name:

PIK3C3

Gene ID:

5289

Gene Aliases:

VPS34

Target Species:

Human