PI3K-C2beta

Background Information:

PI3K-C2β protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and< />intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that< />mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. GenBank NM_002646

Target Class:

Kinase

Family:

PtdIns4P 3-Kinase

Sub Family:

Lipid

Protein Name:

P3C2B

Protein Aliases:

PtdIns-3-kinase C2 subunit beta|C2-PI3K|Phosphoinositide 3-kinase-C2-beta

Accession Number:

NM_002646

UniProt Number:

O00750

Gene Name:

PIK3C2B

Gene ID:

5287

Target Species:

Human