PI3-Kinase (p110alpha(H1047R)/p85alpha)

Background Information:

Complex of N-terminal 6His-tagged recombinant, human p110α full length, containing the mutation H1047R, and untagged recombinant, human p85α full length. The H1047R substitution is a somatic mutation in p110α that has been associated with tumors of the colon, stomach, breast and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).

Target Class:

Kinase

Family:

PtdIns(4,5)P 3-Kinase

Sub Family:

Lipid

Protein Name:

PI3Kalpha

Protein Aliases:

PI3K-alpha|PI3Kalpha|PtdIns-3-kinase subunit alpha|Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|PtdIns-3-kinase subunit p110-alpha|p110alpha|Phosphoinositide-3-kinase catalytic alpha polypeptide|Serine/threonine protein kinase PIK3CA

Accession Number:

U79143

UniProt Number:

P42336

Gene Name:

PIK3CA

Gene ID:

5290

Gene Aliases:

PI3K

Target Species:

Human