Biological Information
Background Information:
The PathHunter® Sargramostim Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses GM-CSF or Sargramostim-induced dimerization of CSF2RB and CSF2RA receptors.The PathHunter Sargramostim Bioassay Kit with control contains all the materials needed to perform a complete assay, including cryopreserved, single-use cells, detection reagents, cell plating reagent, agonist for stimulating the cells, and assay plates. A 10-Plate PathHunter Sargramostim Bioassay Kit is also offered without control but contains all other components listed above to run the assay.
Please reach out to Tech Support at DiscoverXSupportUS@discovery.eurofinsus.com for lot specific CoA.
Protein Name:
CSF2RB
Protein Aliases:
Colony stimulating factor 2 receptor beta common subunit
Accession Number:
NM_000395.2
UniProt Number:
Q6NSJ8
Gene Name:
CSF2RB
Gene ID:
1439
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Bioassay Kits
Application:
Potency, Commercial Release & Stability
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Bioassay Data
Qualified With:
4-aminobutyric acid
Trademark Statement:
Leukine® is a registered trademark of Genzyme Corporation (licensed)
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®