Biological Information

Background Information:

The PathHunter® Sargramostim Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses GM-CSF or Sargramostim-induced dimerization of CSF2RB and CSF2RA receptors.The PathHunter Sargramostim Bioassay Kit with control contains all the materials needed to perform a complete assay, including cryopreserved, single-use cells, detection reagents, cell plating reagent, agonist for stimulating the cells, and assay plates. A 10-Plate PathHunter Sargramostim Bioassay Kit is also offered without control but contains all other components listed above to run the assay.

Please reach out to Tech Support at DiscoverXSupportUS@discovery.eurofinsus.com for lot specific CoA.

Protein Name:

CSF2RB

Protein Aliases:

Colony stimulating factor 2 receptor beta common subunit

Accession Number:

NM_000395.2

UniProt Number:

Q6NSJ8

Gene Name:

CSF2RB

Gene ID:

1439

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Bioassay Kits

Application:

Potency, Commercial Release & Stability

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Bioassay Data

Qualified With:

4-aminobutyric acid

Trademark Statement:

Leukine® is a registered trademark of Genzyme Corporation (licensed)

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®