PathHunter® eXpress IGF1R Functional Assay

Background Information:

The PathHunter® eXpress IGF1R Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated IGF1R dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The cells included overexpress PK-tagged IGF1R and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

IGF1R

Protein Aliases:

Insulin-like growth factor I receptor|IGF-I receptor|CD antigen CD221 [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Accession Number:

NM_000875

UniProt Number:

P08069

Gene Name:

IGF1R

Gene ID:

3480

Gene Aliases:

JTK13|CD221|IGFIR|MGC18216|IGFR

Target Species:

Human

Cell Background:

HEK293