PathHunter® eXpress IFNRL1/IL10RB Dimerization Assay

Background Information:

The PathHunter® IFNRL1/IL10RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-29) induced dimerization of IFNRL1/IL10RB receptors. This product uses EFC technology. The cells included overexpress IFNRL1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IFNRL1/IL10RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Cytokine Receptor

Family:

IL-10 Receptor

Protein Name:

IFN-lambda R1

Protein Aliases:

IFN-lambda-R1|Cytokine receptor class-II member 12|Cytokine receptor family 2 member 12|CRF2-12|Interleukin-28 receptor subunit alpha|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|Likely interleukin or cytokine receptor 2|LICR2

Accession Number:

NM_170743.3

UniProt Number:

Q8IU57

Gene Name:

IFNLR1

Gene ID:

163702

Gene Aliases:

IL28RA|LICR2

Target Species:

Human

Cell Background:

U2OS