PathHunter® eXpress ErbB2/ErbB4 Dimerization Assay

Background Information:

The PathHunter® ErbB2/ErbB4 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. heregulinβ-1) induced dimerization of ErbB2/ErbB4 receptors. This product uses EFC technology. The cells included overexpress ErbB2 target protein fused to PK alongside ErbB4 target protein fused to EA. Upon ligand-induced dimerization of ErbB2/ErbB4, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

HER2

Protein Aliases:

neuro/glioblastoma derived oncogene homolog|human epidermal growth factor receptor 2

Accession Number:

NM_004448.2;

UniProt Number:

P04626

Gene Name:

ERBB2

Gene ID:

2064

Gene Aliases:

NEU|HER-2|CD340|HER2

Target Species:

Human

Cell Background:

U2OS