PathHunter® eXpress DDR1 Functional Assay

Background Information:

The PathHunter® eXpress DDR1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated DDR1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The cells included overexpress PK-tagged DDR1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

DDR1

Protein Aliases:

CD167 antigen-like family member A|Cell adhesion kinase|Discoidin receptor tyrosine kinase|HGK2|Mammary carcinoma kinase 10|MCK-10|Protein-tyrosine kinase 3A|Protein-tyrosine kinase RTK-6|TRK E|Tyrosine kinase DDR|Tyrosine-protein kinase CAK|CD antigen CD167a

Accession Number:

NM_013993.2

UniProt Number:

Q08345

Gene Name:

DDR1

Gene ID:

780

Gene Aliases:

RTK6|CD167

Target Species:

Human

Cell Background:

U2OS