MYO3A, active

Background Information:

N-terminal GST-tagged, recombinant, human MYO3A, amino acids 1-434. Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). Variants in the MYO3A gene have been found to cause variable hearing impairment onset and severity.

Target Class:

Kinase

Family:

STE

Sub Family:

Serine/threonine kinase

Protein Name:

MYO3A

Accession Number:

BC119811.1

UniProt Number:

Q8NEV4

Gene Name:

MYO3A

Gene ID:

53904

Target Species:

Human