Mnk2, active

Background Information:

MnK2, MAPK Interacting Serine/Threonine Kinase 2, is a member of the calcium/calmodulin-dependent kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. GenBank NM_017572

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

MNK2

Protein Aliases:

Putative map kinase interacting kinase

Accession Number:

NM_017572.3; NM_199054.2

UniProt Number:

Q9HBH9

Gene Name:

MKNK2

Gene ID:

2872

Gene Aliases:

MNK2

Target Species:

Human