Biological Information

Background Information:

MLK4 (Mixed-Lineage Kinase 4) is a serine/threonine protein kinase that belongs to the mixed lineage kinase family of MAP3Ks (mitogen-activated protein Kinase kinase kinases). MLK4 has been shown to activate several downstream signaling pathways, including the c-Jun N-terminal kinase (JNK) pathway, the p38 MAPK pathway, and the NF-κB pathway, and it has been suggested to play a role in the regulation of cell survival, apoptosis, and inflammation. Research has suggested that MLK4 may also be involved in the regulation of several other physiological processes, including cardiovascular function and cancer progression. MLK4 has been implicated in the development and progression of several types of cancer, including breast cancer, prostate cancer, and pancreatic cancer, and efforts to develop small-molecule inhibitors of the kinase are underway as potential therapies for these conditions.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

MLK4

Protein Aliases:

Mixed lineage kinase 4

Accession Number:

BC136649.1

UniProt Number:

Q5TCX8

Gene Name:

MAP3K21

Gene ID:

84451

Gene Aliases:

KIAA1804|MLK4

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only