Met (Y1248H), active

Background Information:

MET tyrosine kinase is a high-affinity receptor for hepatocyte growth factor/scatter factor. Signaling via this receptor-ligand pair has been shown to affect a wide range of biological activities, including angiogenesis, cellular motility, growth, invasion, and morphogenic differentiation. Mutations in the MET tyrosine kinase receptor have been identified in both hereditary and sporadic forms of papillary renal carcinoma and implicated in tumor growth, invasion, and metastasis. GenBank J02958. The recombinant protein contains the amino acid substitutions A1209G and V1290L with reference to GenBank J02958. Both substitutions are reported in GenBank BU595386, BQ315895 and BQ316491.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Met

Protein Aliases:

hepatocyte growth factor receptor

Accession Number:

NM_000245.2

UniProt Number:

P08581

Gene Name:

MET

Gene ID:

4233

Gene Aliases:

HGFR|RCCP2|DFNB97

Target Species:

Human