MEK2, active

Background Information:

MEK2 protein is a dual specificity protein kinase that belongs to the MAP Kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP Kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. It catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). GenBank NM_030662

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

MEK2

Protein Aliases:

MAPKK 2|ERK activator kinase 2|MAPK/ERK kinase 2|MEK 2

Accession Number:

NM_030662

UniProt Number:

P36507

Gene Name:

MAP2K2

Gene ID:

5605

Gene Aliases:

MEK2|MKK2|PRKMK2

Target Species:

Human