MAP4K4, active

Background Information:

MAP4K4 is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

HGK

Protein Aliases:

HPK/GCK-like kinase|hepatocyte progenitor kinase-like/germinal center kinase-like kinase

Accession Number:

NM_004834.4

UniProt Number:

O95819

Gene Name:

MAP4K4

Gene ID:

9448

Gene Aliases:

HGK|NIK|FLH21957|KIAA0687

Target Species:

Human