LATS2, active

Background Information:

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. GenBank NM_014572.2 / GenBank BC038112

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

LATS2

Protein Aliases:

Kinase phosphorylated during mitosis protein|Large tumor suppressor homolog 2|Serine/threonine-protein kinase kpm|Warts-like kinase

Accession Number:

NM_014572.2; BC038112.1

UniProt Number:

Q9NRM7

Gene Name:

LATS2

Gene ID:

26524

Target Species:

Human