JAK1, active

Background Information:

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-α/beta and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

JAK1

Protein Aliases:

JAK-1

Accession Number:

NM_002227

UniProt Number:

P23458

Gene Name:

JAK1

Gene ID:

3716

Gene Aliases:

JAK1A|JTK3

Target Species:

Human