InCELL Hunter™ eXpress A549 GLP Methyltransferase Assay

Background Information:

The InCELL Hunter™ eXpress A549 GLP Methyltransferase Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with regulators of epigenetics pathways. This kit assesses compound-engagement-based stabilization of GLP via detection of GLP levels. This product uses EFC technology. The cells included overexpress GLP target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Epigenetic

Family:

Histone Methyltransferase (HMT)

Sub Family:

Writer

Protein Name:

EHMT1

Protein Aliases:

GLP

Accession Number:

NM_024757

UniProt Number:

Q9H9B1

Gene Name:

EHMT1

Gene ID:

79813

Gene Aliases:

Eu-HMTase1|FLJ12879|KIAA1876|bA188C12.1|KMT1D

Target Species:

Human

Cell Background:

A549