Fms, active

Background Information:

CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. GenBank U63963

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Fms (CSFR)

Protein Aliases:

CSF-1-R|CSF-1R|M-CSF-R|Proto-oncogene c-Fms|CD antigen CD115

Accession Number:

NM_005211.2

UniProt Number:

P07333

Gene Name:

CSF1R

Gene ID:

1436

Gene Aliases:

C-FMS|CSFR|CD115

Target Species:

Human