Flt1, active

Background Information:

Two high affinity VEGF receptors, FLT1 (VEGFR-1, activated by placental growth factor PlGF) and KDR (Flk-1/VEGFR-2, activated by VEGF), have been identified. These receptors can be divided into three structural regions: seven extracellular Ig-like domains that contain the growth factor binding sites, a single polypeptide chain hydrophobic trans-membrane sequence, and intracellular cytoplasmic domains that confer the tyrosine kinase activity required for signal transduction. VEGF-B and VEGF-D homologues bind with high affinity to FLT1 (fms-related tyrosine kinase 1, vascular endothelial growth factor/vascular permeability factor receptor). GenBank AF063657

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Flt-1 (VEGFR1)

Protein Aliases:

vascular endothelial growth factor receptor 1|vascular permeability factor receptor

Accession Number:

AF063657

UniProt Number:

P17948

Gene Name:

FLT1

Gene ID:

2321

Gene Aliases:

FLT|FRT|VEGFR1

Target Species:

Human