Fes/Fps, active

Background Information:

The cyclin-dependent kinases (CDKs), are a family of serine threonine protein kinases, that control the cell division cycle. In mammals, nine different CDKs (cdk 1 to cdk 9) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. The cdk2 promotes the G1/S transition and progression through the S phase when bound to specific cyclins (E and A). Recent evidences indicate that CDK2 is involved in cell cycle independent functions such as DNA damage repair. GenBank X06292

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

FES

Protein Aliases:

Oncogene FES, feline sarcoma virus|c-fes/fps protein

Accession Number:

NM_002005.2

UniProt Number:

P07332

Gene Name:

FES

Gene ID:

2242

Gene Aliases:

FPS

Target Species:

Human