Biological Information

Background Information:

DNA-dependent helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks in a BRCA1-dependent manner. Identified as a tumour suppressor in DNA interstrand cross-link repair and double-strand break repair. Mutations in FANCJ are linked to Fanconi anemia (FA), hereditary breast, ovarian and colon cancers, as well as melanoma and prostate cancer.

Target Class:

Helicase

Family:

DEAH

Sub Family:

DNA helicase

Protein Aliases:

BRIP1, BACH1

Accession Number:

NM_032043.3

UniProt Number:

Q9BX63

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology