EphA3, active

Background Information:

Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Recruitment of CrkII and activation of Rho Signaling are responsible for EphA3-mediated cell rounding, blebbing and de-adhesion. This response is activated by ephrin-A5-mediated receptor clustering and EphA3 tyrosine kinase activity. GenBank NM_005233

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphA3

Protein Aliases:

EPH-like kinase 4|EK4|hEK4|HEK|Human embryo kinase|Tyrosine-protein kinase TYRO4|Tyrosine-protein kinase receptor ETK1|Eph-like tyrosine kinase 1

Accession Number:

NM_005233.3; NM_182644.1

UniProt Number:

P29320

Gene Name:

EPHA3

Gene ID:

2042

Gene Aliases:

HEK|HEK4

Target Species:

Human