EGFR (T790M, L858R), active

Background Information:

EGFR (Epidermal Growth Factor Receptor), also known as ErbB1 or HER1, is a transmembrane receptor protein that belongs to the family of receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth, proliferation, differentiation, and survival. EGFR is activated by binding to specific ligands, such as epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha), which leads to dimerization of the receptor and autophosphorylation of specific tyrosine residues on the intracellular domain. This activates downstream signaling pathways, such as the MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, which regulate gene expression and other cellular functions. Aberrant activation of EGFR has been implicated in several diseases, including cancer, inflammatory disorders, and neurodegenerative diseases.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EGFR

Protein Aliases:

erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)|erb-b2 receptor tyrosine kinase 1

Accession Number:

NM_005228.3; NM_201282.1; NM_201283.1; NM_201284.1

UniProt Number:

P00533

Gene Name:

EGFR

Gene ID:

1956

Gene Aliases:

ERBB1

Target Species:

Human