CHK2, active

Background Information:

Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK2 might have a redundant and supportive role in checkpoints, but its role in ionizing radiation-induced apoptosis is more prominent. However, its role in other DNA-damage-induced apoptosis mechanisms is less well established. CHK2 inhibitors are expected to sensitize proliferating cells to chemotherapy-induced apoptosis. GenBank NM_007194

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

CHK2

Protein Aliases:

CHK2 checkpoint homolog|Cds1 homolog|Hucds1|hCds1|Checkpoint kinase 2

Accession Number:

NM_001005735.1; NM_007194.3; NM_145862.2

UniProt Number:

O96017

Gene Name:

CHEK2

Gene ID:

11200

Gene Aliases:

CDS1|CHK2|HuCds1|PP1425|bA444G7|RAD53

Target Species:

Human