Biological Information

Background Information:

Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK1 regulates numerous checkpoint pathways, including S-phase and G2-M checkpoints. Other potential CHK1 functions include replication, chromatin remodeling and DNA repair. CHK1 inhibitors may sensitize tumors to chemotherapy and radiotherapy. GenBank AF016582

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

CHK1

Protein Aliases:

CHK1 checkpoint homolog|Cell cycle checkpoint kinase|Checkpoint kinase-1

Accession Number:

NM_001274.3

UniProt Number:

O14757

Gene Name:

CHEK1

Gene ID:

1111

Gene Aliases:

CHK1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology