ChemiSCREEN™ S1P3 Lysophospholipid Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ S1P3 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. S1P) based activation of S1PR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses S1PR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of S1PR3 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Lysophospholipid (S1P)

Sub Family:

Class A

Protein Name:

S1P3

Protein Aliases:

EDG3|Endothelial differentiation G-protein coupled receptor 3|Lysophospholipid receptor B3|Sphingosine 1-phosphate receptor Edg-3|S1P receptor Edg-3

Accession Number:

NM_005226

UniProt Number:

Q99500

Gene Name:

S1PR3

Gene ID:

1903

Gene Aliases:

EDG-3

Target Species:

Human

Cell Background:

Chem-1