ChemiSCREEN™ PK2 Prokineticin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ PK2 Prokineticin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PROKR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PROKR2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Prokineticin

Sub Family:

Class A

Protein Name:

PK2

Protein Aliases:

G-protein coupled receptor 73-like 1|G-protein coupled receptor I5E

Accession Number:

NM_144773

UniProt Number:

Q8NFJ6

Gene Name:

PROKR2

Gene ID:

128674

Gene Aliases:

GPR73b|PKR2|GPRg2|dJ680N4.3|GPR73L1

Target Species:

Human

Cell Background:

Chem-1