ChemiSCREEN™ NTR1 Neurotensin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ NTR1 Neurotensin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neurotensin) based activation of NTSR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NTSR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NTSR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Neurotensin

Sub Family:

Class A

Protein Name:

NT1

Protein Aliases:

NTR1|High-affinity levocabastine-insensitive neurotensin receptor|NTRH

Accession Number:

NM_002531

UniProt Number:

P30989

Gene Name:

NTSR1

Gene ID:

4923

Gene Aliases:

NTR|NTRR

Target Species:

Human

Cell Background:

Chem-1