Biological Information
Background Information:
The ChemiSCREEN™ GLP-2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. GLP-2) based activation of GLP2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GLP2R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of GLP2R , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Glucagon
Sub Family:
Class B
Protein Name:
GLP-2
Protein Aliases:
GLP-2-R|GLP-2R
Accession Number:
NM_004246
UniProt Number:
O95838
Gene Name:
GLP2R
Gene ID:
9340
Target Species:
Human
Cell Background:
Chem-11
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Clinical Relevance
Therapeutic Area:
Metabolic Diseases
Additional Information
Brand:
ChemiSCREEN™