ChemiSCREEN™ FPRL1 N-Formylpeptide Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ FPRL1 N-Formylpeptide Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. N-formyl peptides) based activation of FPR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FPR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of FPR2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Formylpeptide

Sub Family:

Class A

Protein Name:

FPR2

Protein Aliases:

FMLP-R-I|Formyl peptide receptor-like 1|HM63|Lipoxin A4 receptor|LXA4 receptor|RFP

Accession Number:

NM_001462

UniProt Number:

P25090

Gene Name:

FPR2

Gene ID:

2358

Gene Aliases:

LXA4R|HM63|FPRH2|FMLPX|FPR2A|FMLP-R-II|ALXR|FPR|FMLP

Target Species:

Human

Cell Background:

Chem-1