ChemiSCREEN™ CysLT1 Leukotriene Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CysLT1 Leukotriene Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. leukotriene) based activation of CysLT1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CysLT1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CysLT1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Leukotriene

Sub Family:

Class A

Protein Name:

CysLT1

Accession Number:

NM_006639

UniProt Number:

Q9Y271

Gene Name:

CYSLTR1

Gene ID:

10800

Gene Aliases:

CysLT1|CysLT(1)|CYSLT1R

Target Species:

Human

Cell Background:

Chem-1