ChemiSCREEN™ CXCR4 Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CXCR4 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL12/SDF-1α) based activation of CXCR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR4 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR4 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CXCR4

Protein Aliases:

CXCR-4|Fusin|Leukocyte-derived seven transmembrane domain receptor|LESTR|Pre-B-cell-derived chemokine receptor|PB-CKR|Stromal cell-derived factor 1 receptor|SDF-1 receptor|CD antigen CD184

Accession Number:

M99293

UniProt Number:

P61073

Gene Name:

CXCR4

Gene ID:

7852

Gene Aliases:

LESTR|NPY3R|HM89|NPYY3R|D2S201E|fusin|HSY3RR|NPYR|CD184

Target Species:

Human

Cell Background:

Chem-1