ChemiSCREEN™ CXCR1 Chemokine Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CXCR1 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CXCR1 (IL-8RA)

Protein Aliases:

CXCR-1|CDw128a|High affinity interleukin-8 receptor A|IL-8R A|IL-8 receptor type 1|CD antigen CD181

Accession Number:

NM_000634

UniProt Number:

P25024

Gene Name:

CXCR1

Gene ID:

3577

Gene Aliases:

CKR-1|CDw128a|CD181

Target Species:

Human

Cell Background:

Chem-1