ChemiSCREEN™ CCK2 Cholecystokinin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CCK2 Cholecystokinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. cholecystokinin) based activation of CCKBR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCKBR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCKBR , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Cholecystokinin

Sub Family:

Class A

Protein Name:

CCK2 (CCKB)

Protein Aliases:

CCK-BR|Cholecystokinin-2 receptor|CCK2-R

Accession Number:

AY322551

UniProt Number:

P32239

Gene Name:

CCKBR

Gene ID:

887

Gene Aliases:

CCKRB

Target Species:

Human

Cell Background:

Chem-1